Publications before University of Pennsylvania

Evidence for modulation of oxygen old pub3

Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases.

Pan J‡, Wenger ES‡, Matthews ML‡, Pollock CJ, Bhardwaj M, Kim AJ, Allen BD, Grossman RB, Krebs C, and Bollinger, Jr. JM. (‡equal contribution). Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxogl.utarate-Dependent Oxygenases.. J. Am. Chem. Soc 141, 15153−15165 (2019)

Chemoproteomic profiling and discovery of protein electrophiles in human cells

Matthews ML*, He L, Olson EJ, Horning BD, Correia BE, Yates JR, III, Dawson PE & Cravatt BF*. . Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nat. Chem.  9, 234–243 (2017)

Deisgn of Benzoxathiazin old pub5

Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor

Kornahrens, A, Cognetta, A Brody D, Matthews ML, Cravatt BF & Boger D.. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor. J. Am. Chem. Soc.  139, 7052–7061 (2017)

Vanadyl as a stable structure old pub4

Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.

Martinie RJ, Pollock CJ, Matthews ML, Bollinger JM Jr, Krebs C, Silakov A. . Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.. Inorg. Chem.  56, 13382-13389 (2017)

electronic structure of the ferryl old pub10

Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.

 Srnec M, Wong SD, Matthews ML, Krebs C, Bollinger JM, Jr. & Solomon EI. . Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.. J. Am. Chem. Soc.  138, 5110-5122 (2016)

Chemical Proteomic old pub7

Chemical proteomic profiling of human methyltransferases

Horning BD, Suciu RM, Ghadiri D, Ulanovskaya O, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H & Cravatt BF. . Chemical proteomic profiling of human methyltransferases. J. Am. Chem. Soc.  138, 13335–13343 (2016)

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Matthews ML*, Chang WC, Layne AP, Miles LA, Krebs C & Bollinger JM, Jr.* . Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase. Nat. Chem. Biol.  10, 209-215 (2014)

Design of activated serine-containing catalytic triads with atomic-level accuracy

Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF & Baker D. . Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat. Chem. Biol.  10, 386-391 (2014)

Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2

Wong SD, Srnec M, Matthews ML, Liu LV, Kwak Y, Park K, Bell CB, Alp EE, Zhao JY, Yoda Y, Kitao S, Seto M, Krebs C, Bollinger JM, Jr. & Solomon EI. . Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2. Nature  499, 320-323 (2013)

Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations

Krebs C, Dassama LMK, Matthews ML, Jiang W, Price JC, Korboukh V, Li N & Bollinger JM, Jr. . Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations. Coord. Chem. Rev.  257, 234-243 (2013)