Publications before University of Pennsylvania

highly selective inhibitors old pub9

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

Chang JW, Niphakis MJ, Lum KM, Cognetta AB, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH & Cravatt BF. . Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem. Biol.  19, 579-588 (2012)

the nonribosomal peptide old pub14

The nonribosomal peptide synthetase enzyme DdaD tethers N(b)-fumaramoyl-L-2,3-diaminopropionate for Fe(II)/a-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis

Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Jr. Kelleher NL & Walsh CT. . The nonribosomal peptide synthetase enzyme DdaD tethers N(b)-fumaramoyl-L-2,3-diaminopropionate for Fe(II)/a-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. J. Am. Chem. Soc.  132, 15773-15781 (2010)

subtrate triggered formation old pub17

Substrate-triggered formation and remarkable stability of the C–H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

Matthews ML, Krest CM, Barr EW, Vaillancourt FH, Walsh CT, Green MT, Krebs C & Bollinger JM, Jr. . Substrate-triggered formation and remarkable stability of the C–H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2. Biochemistry 48, 4331-4343 (2009)

Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.

Matthews ML, Neumann CS, Miles LA, Grove TL, Booker SJ, Krebs C, Walsh CT & Bollinger JM, Jr. . Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.. Proc. Natl. Acad. Sci. USA  106, 17723-17728 (2009)

Myo-inositol oxygenase: a radical new pathway for O2

Bollinger JM, Jr., Diao Y, Matthews ML, Xing G & Krebs C. . Myo-inositol oxygenase: a radical new pathway for O2. Dalton Trans.  905-914 (2009)

spectroscopic evidence old pub 20

Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the a-ketoglutarate-dependent halogenase CytC3 from Streptomyces

Fujimori DG, Barr EW, Matthews ML, Koch GM, Yonce JR, Walsh CT, Bollinger JM, Jr., Krebs C & Riggs-Gelasco PJ. . Spectroscopic evidence for a high-spin Br-Fe(IV)-oxo intermediate in the a-ketoglutarate-dependent halogenase CytC3 from Streptomyces. J. Am. Chem. Soc.  129, 13408-13409 (2007)

AurF from Streptomyces old pub19

AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases

Krebs C, Matthews ML, Jiang W & Bollinger JM, Jr. . AurF from Streptomyces thioluteus and a possible new family of manganese/iron oxygenases. Biochemistry  46, 10413-10418 (2007)

Probing the reaction old pub21

Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme

Matthews ML, Periyannan G, Hajdin C, Sidgel TK, Bennett B & Crowder MW. . Probing the reaction mechanism of the D-ala-D-ala dipeptidase, VanX, by using stopped-flow kinetic and rapid-freeze quench EPR studies on the Co(II)-substituted enzyme. J. Am. Chem. Soc.  128, 13050-13051 (2006)

A five-coordinate metal center in Co(II)-substituted VanX

Breece RM, Costello A, Bennett B, Sigdel TK, Matthews ML, Tierney DL & Crowder MW. . A five-coordinate metal center in Co(II)-substituted VanX. J. Biol. Chem.  280, 11074-11081 (2005)