Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications
Matthews ML. Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications. WO 20190204336A1 (2019)
Matthews ML. Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications. WO 20190204336A1 (2019)
Dettling SE, Ahmadi M, Lin Z, Matthews ML*. (2020). Discovery of electrophiles and profiling of enzyme cofactors. Curr. Protoc. Chem. Biol., 12, e86.
Lin Z, Wang X, Bustin KA, He L, Suciu RM, Schek N, Ahmadi M, Hu K, Olsen EJ, Parsons WH, Witze ES, Morton PD, Gregus AM, Buczynski MW, Matthews ML. Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv (2020)
Pan J‡, Wenger ES‡, Matthews ML‡, Pollock CJ, Bhardwaj M, Kim AJ, Allen BD, Grossman RB, Krebs C, and Bollinger, Jr. JM. (‡equal contribution). Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxogl.utarate-Dependent Oxygenases.. J. Am. Chem. Soc 141, 15153−15165 (2019)
EJ Blaesi, GP Palowitch, K Hu, AJ Kim, HR Rose, RB Alapati, MG Lougee, HJ Kim, KO Tan, AT Taguchi, TN Laremore, RG Griffin*, C Krebs*, ML Matthews*, A Silakov*, JM Bollinger, Jr.*, BD Allen*, AK Boal*. (*co-corresponding authors).. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. PNAS 115 (40), 10022-10027 (2018)
Martinie RJ, Pollock CJ, Matthews ML, Bollinger JM Jr, Krebs C, Silakov A. . Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.. Inorg. Chem. 56, 13382-13389 (2017)
Kornahrens, A, Cognetta, A Brody D, Matthews ML, Cravatt BF & Boger D.. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor. J. Am. Chem. Soc. 139, 7052–7061 (2017)
Matthews ML*, He L, Olson EJ, Horning BD, Correia BE, Yates JR, III, Dawson PE & Cravatt BF*. . Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nat. Chem. 9, 234–243 (2017)
Horning BD, Suciu RM, Ghadiri D, Ulanovskaya O, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H & Cravatt BF. . Chemical proteomic profiling of human methyltransferases. J. Am. Chem. Soc. 138, 13335–13343 (2016)
Srnec M, Wong SD, Matthews ML, Krebs C, Bollinger JM, Jr. & Solomon EI. . Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.. J. Am. Chem. Soc. 138, 5110-5122 (2016)
Matthews Lab
231 South 34th Street
Chemistry 1973 Building, Room 234
Vagelos 2210, Philadelphia, PA 19104
Phone: (215) 573-7995
Email: megamatt@sas.upenn.edu