Lin TOC

Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets

Lin, Z. Wang, X. Bustin, K.A., Shishikura, K., McKnight, N.R., He, L., Suciu, R.M., Hu, K., Han, X., Ahmadi, M., Olson, E.J., Parsons, W.H., Matthews M.L.

Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Central Science Article ASAP. DOI: 10.1021/acscentsci.1c00616

Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications

Matthews ML. Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications. WO 20190204336A1 (2019)

Discovery of electrophiles and profiling of enzyme cofactors

Dettling SE, Ahmadi M, Lin Z, Matthews ML*. (2020). Discovery of electrophiles and profiling of enzyme cofactors. Curr. Protoc. Chem. Biol., 12, e86.

hydrazines as versatile chemical biology old pub1

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes

Lin Z, Wang X, Bustin KA, He L, Suciu RM, Schek N, Ahmadi M, Hu K, Olsen EJ, Parsons WH, Witze ES, Morton PD, Gregus AM, Buczynski MW, Matthews ML. Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv (2020)

Evidence for modulation of oxygen old pub3

Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases.

Pan J, Wenger ES, Matthews ML, Pollock CJ, Bhardwaj M, Kim AJ, Allen BD, Grossman RB, Krebs C, and Bollinger, Jr. JM. (equal contribution). Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxogl.utarate-Dependent Oxygenases.. J. Am. Chem. Soc 141, 15153−15165 (2019)

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

EJ Blaesi, GP Palowitch, K Hu, AJ Kim, HR Rose, RB Alapati, MG Lougee, HJ Kim, KO Tan, AT Taguchi, TN Laremore, RG Griffin*, C Krebs*, ML Matthews*, A Silakov*, JM Bollinger, Jr.*, BD Allen*, AK Boal*. (*co-corresponding authors).. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. PNAS 115 (40), 10022-10027 (2018)

Vanadyl as a stable structure old pub4

Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.

Martinie RJ, Pollock CJ, Matthews ML, Bollinger JM Jr, Krebs C, Silakov A. . Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.. Inorg. Chem.  56, 13382-13389 (2017)

Deisgn of Benzoxathiazin old pub5

Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor

Kornahrens, A, Cognetta, A Brody D, Matthews ML, Cravatt BF & Boger D.. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor. J. Am. Chem. Soc.  139, 7052–7061 (2017)

Chemoproteomic profiling and discovery of protein electrophiles in human cells

Matthews ML*, He L, Olson EJ, Horning BD, Correia BE, Yates JR, III, Dawson PE & Cravatt BF*. . Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nat. Chem.  9, 234–243 (2017)

Chemical Proteomic old pub7

Chemical proteomic profiling of human methyltransferases

Horning BD, Suciu RM, Ghadiri D, Ulanovskaya O, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H & Cravatt BF. . Chemical proteomic profiling of human methyltransferases. J. Am. Chem. Soc.  138, 13335–13343 (2016)