Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications
Matthews ML. Chemoproteomic profiling of protein electrophilic and oxidative post-translational modifications. WO 20190204336A1 (2019)
Discovery of electrophiles and profiling of enzyme cofactors
Dettling SE, Ahmadi M, Lin Z, Matthews ML*. (2020). Discovery of electrophiles and profiling of enzyme cofactors. Curr. Protoc. Chem. Biol., 12, e86.
Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes
Lin Z, Wang X, Bustin KA, He L, Suciu RM, Schek N, Ahmadi M, Hu K, Olsen EJ, Parsons WH, Witze ES, Morton PD, Gregus AM, Buczynski MW, Matthews ML. Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv (2020)
Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases.
Pan J‡, Wenger ES‡, Matthews ML‡, Pollock CJ, Bhardwaj M, Kim AJ, Allen BD, Grossman RB, Krebs C, and Bollinger, Jr. JM. (‡equal contribution). Evidence for Modulation of Oxygen-Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxogl.utarate-Dependent Oxygenases.. J. Am. Chem. Soc 141, 15153−15165 (2019)
Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical
EJ Blaesi, GP Palowitch, K Hu, AJ Kim, HR Rose, RB Alapati, MG Lougee, HJ Kim, KO Tan, AT Taguchi, TN Laremore, RG Griffin*, C Krebs*, ML Matthews*, A Silakov*, JM Bollinger, Jr.*, BD Allen*, AK Boal*. (*co-corresponding authors).. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. PNAS 115 (40), 10022-10027 (2018)
Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.
Martinie RJ, Pollock CJ, Matthews ML, Bollinger JM Jr, Krebs C, Silakov A. . Vanadyl as a Stable Structural Mimic of Reactive Ferryl Intermediates in Mononuclear Nonheme-Iron Enzymes.. Inorg. Chem. 56, 13382-13389 (2017)
Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor
Kornahrens, A, Cognetta, A Brody D, Matthews ML, Cravatt BF & Boger D.. Design of benzoxathiazin-3-one 1,1-dioxides as a new class of irreversible serine hydrolase inhibitors: discovery of a uniquely selective PNPLA4 inhibitor. J. Am. Chem. Soc. 139, 7052–7061 (2017)
Chemoproteomic profiling and discovery of protein electrophiles in human cells
Matthews ML*, He L, Olson EJ, Horning BD, Correia BE, Yates JR, III, Dawson PE & Cravatt BF*. . Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nat. Chem. 9, 234–243 (2017)
Chemical proteomic profiling of human methyltransferases
Horning BD, Suciu RM, Ghadiri D, Ulanovskaya O, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H & Cravatt BF. . Chemical proteomic profiling of human methyltransferases. J. Am. Chem. Soc. 138, 13335–13343 (2016)
Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.
Srnec M, Wong SD, Matthews ML, Krebs C, Bollinger JM, Jr. & Solomon EI. . Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.. J. Am. Chem. Soc. 138, 5110-5122 (2016)
