Chemoproteomic profiling and discovery of protein electrophiles in human cells

Matthews ML*, He L, Olson EJ, Horning BD, Correia BE, Yates JR, III, Dawson PE & Cravatt BF*. . Chemoproteomic profiling and discovery of protein electrophiles in human cells. Nat. Chem.  9, 234–243 (2017)

Chemical Proteomic old pub7

Chemical proteomic profiling of human methyltransferases

Horning BD, Suciu RM, Ghadiri D, Ulanovskaya O, Matthews ML, Lum KM, Backus KM, Brown SJ, Rosen H & Cravatt BF. . Chemical proteomic profiling of human methyltransferases. J. Am. Chem. Soc.  138, 13335–13343 (2016)

electronic structure of the ferryl old pub10

Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.

 Srnec M, Wong SD, Matthews ML, Krebs C, Bollinger JM, Jr. & Solomon EI. . Electronic structure of the ferryl intermediate in the a-ketoglutarate dependent non-heme iron halogenase SyrB2: Contributions to H-atom abstraction reactivity.. J. Am. Chem. Soc.  138, 5110-5122 (2016)

Design of activated serine-containing catalytic triads with atomic-level accuracy

Rajagopalan S, Wang C, Yu K, Kuzin AP, Richter F, Lew S, Miklos AE, Matthews ML, Seetharaman J, Su M, Hunt JF, Cravatt BF & Baker D. . Design of activated serine-containing catalytic triads with atomic-level accuracy. Nat. Chem. Biol.  10, 386-391 (2014)

Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase

Matthews ML*, Chang WC, Layne AP, Miles LA, Krebs C & Bollinger JM, Jr.* . Direct nitration and azidation of aliphatic carbons by an iron-dependent halogenase. Nat. Chem. Biol.  10, 209-215 (2014)

Aza-b-lactam compounds and methods of using

Cravatt BF, Zuhl AM, Bachovchin DA, Matthews ML, Fu GC, Mohr JT, Berlin JM. Aza-b-lactam compounds and methods of using. WO 2013152272 A1 (2013).

Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2

Wong SD, Srnec M, Matthews ML, Liu LV, Kwak Y, Park K, Bell CB, Alp EE, Zhao JY, Yoda Y, Kitao S, Seto M, Krebs C, Bollinger JM, Jr. & Solomon EI. . Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2. Nature  499, 320-323 (2013)

Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations

Krebs C, Dassama LMK, Matthews ML, Jiang W, Price JC, Korboukh V, Li N & Bollinger JM, Jr. . Novel approaches for the accumulation of oxygenated intermediates to multi-millimolar concentrations. Coord. Chem. Rev.  257, 234-243 (2013)

highly selective inhibitors old pub9

Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

Chang JW, Niphakis MJ, Lum KM, Cognetta AB, Wang C, Matthews ML, Niessen S, Buczynski MW, Parsons LH & Cravatt BF. . Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem. Biol.  19, 579-588 (2012)

Remote enzyme microsurgery

Bollinger JM, Jr. & Matthews ML. . Remote enzyme microsurgery. Science  327, 1337-1338 (2010)