Publications at University of Pennsylvania

Discovery of electrophiles and profiling of enzyme cofactors

Dettling SE, Ahmadi M, Lin Z, Matthews ML*. (2020). Discovery of electrophiles and profiling of enzyme cofactors. Curr. Protoc. Chem. Biol., 12, e86.

hydrazines as versatile chemical biology old pub1

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes

Lin Z, Wang X, Bustin KA, He L, Suciu RM, Schek N, Ahmadi M, Hu K, Olsen EJ, Parsons WH, Witze ES, Morton PD, Gregus AM, Buczynski MW, Matthews ML. Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv (2020)

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

EJ Blaesi, GP Palowitch, K Hu, AJ Kim, HR Rose, RB Alapati, MG Lougee, HJ Kim, KO Tan, AT Taguchi, TN Laremore, RG Griffin*, C Krebs*, ML Matthews*, A Silakov*, JM Bollinger, Jr.*, BD Allen*, AK Boal*. (*co-corresponding authors).. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. PNAS 115 (40), 10022-10027 (2018)