Bustin, KA, Abbas, A, Abt, MC, Zackular, JP, Matthews, ML*. Characterizing metabolic drivers of Clostridioides difficile infection with activity-based hydrazine probes. Front. Pharmacol. 2023. 14, 1074619.
Publications at University of Pennsylvania
Wang X, Lin Z, Bustin KA, McKnight NR, Parsons WH, Matthews ML*. Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J. Am. Chem. Soc. 2022. 144, 5377-5388.
Activity-Based Hydrazine Probes for Protein Profiling of Electrophilic Functionality in Therapeutic Targets. ACS Central Science Article ASAP. DOI: 10.1021/acscentsci.1c00616
Dettling SE, Ahmadi M, Lin Z, Matthews ML*. (2020). Discovery of electrophiles and profiling of enzyme cofactors. Curr. Protoc. Chem. Biol., 12, e86.
Lin Z, Wang X, Bustin KA, He L, Suciu RM, Schek N, Ahmadi M, Hu K, Olsen EJ, Parsons WH, Witze ES, Morton PD, Gregus AM, Buczynski MW, Matthews ML. Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv (2020)
EJ Blaesi, GP Palowitch, K Hu, AJ Kim, HR Rose, RB Alapati, MG Lougee, HJ Kim, KO Tan, AT Taguchi, TN Laremore, RG Griffin*, C Krebs*, ML Matthews*, A Silakov*, JM Bollinger, Jr.*, BD Allen*, AK Boal*. (*co-corresponding authors).. Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical. PNAS 115 (40), 10022-10027 (2018)