Excited to share Xie’s paper showing hydrazines can be made to be potent selective glox inhibitors is online at JACS (https://doi.org/10.1021/jacs.1c12748). Congrats Xie!

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https://doi.org/10.1021/jacs.1c12748

 

Excited to share Tom’s paper showing hydrazines can covalently target multiple classes of enzymes is online at ACS Central Science (10.1021/acscentsci.1c00616). Congrats to the whole lab and thanks to our collaborators!

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https://pubs.acs.org/doi/10.1021/acscentsci.1c00616

Tom presented his work in a talk titled “Discovery of cofactor-derived covalencies using chemical proteomics” at the virtual UPenn Chemistry-Biology Interface summer retreat! Great job Tom!

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Tom CBI

Tom gives talk at the virtual UPenn Chemistry-Biology Interface summer retreat!

Katie presented some of her progress on the chemoproteomic profiling of cofactor-dependent enzymes in Clostridioides difficile (C. difficile) at a meeting of the UPenn C. difficile community!

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Thrilled to share our first BioRxiv preprint about Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes

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